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In vitro and in vivo investigations of targeted chemotherapy with magnetic nanoparticles
Institution:1. Department of Otorhinolaryngology, Head and Neck Surgery, Friedrich-Alexander-University Erlangen-Nürnberg, Waldstr. 1, 91054 Erlangen, Germany;3. Chemicell GmbH, Berlin, Germany;4. Physics Department E17, TU-München, Germany;1. Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada;2. Biomedical Engineering Department, The Cleveland Clinic Foundation, Cleveland, Ohio, USA;1. Department of Electrical, Computer and IT Engineering, Qazvin Branch, Islamic Azad University, Qazvin, Iran;2. Department of Computer Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran;3. Soft Computing Laboratory, Computer Engineering and Information Technology Department, Amirkabir University of Technology (Tehran Polytechnic), 424 Hafez Ave., Tehran, Iran;1. Liverpool Ocular Oncology Service, St. Paul’s Eye Unit, Royal Liverpool University Hospital, Liverpool L7 8XP, UK;2. Ocular Oncology Service, Departments of Ophthalmology and Radiation Oncology, University of California, San Francisco, CA 94143, USA;1. KLE University’s College of Pharmacy, Nehru Nagar, Belgaum, 590010 Karnataka, India;2. Dr. Prabhakar Kore Basic Science Research Center, KLE University, Belgaum, 590010 Karnataka, India;3. Department of Pathology, KLE University’s Jawaharlal Nehru Medical College, Nehru Nagar, Belgaum, 590010 Karnataka, India;1. Lincoln University College, Petaling Jaya, Malaysia;2. International Medical University, Kuala Lumpur, Malaysia;3. Universiti Kebangsaan Malaysia, Bangi, Malaysia;4. Panjab University, Chandigarh, Panjab, India;5. Central University of Rajasthan, Ajmer, Rajasthan, India;1. Faculty of Physics, University of Isfahan, Isfahan, 81746-73441, Iran;2. Institute of Physics, University of Freiburg, Hermann-Herder-Straße 3, 79104, Freiburg, Germany;3. Institute of Biomedical Engineering and Informatics (BMTI), Technische Universität Ilmenau, Gustav-Kirchhoff-Straße 2, 98693, Ilmenau, Germany
Abstract:Magnetic drug targeting is a local drug delivery system. Electromicroscopic pictures document the ferrofluid enrichment in the intracellular space in vitro. In vivo experiments were performed in VX2 tumor-bearing rabbits using magnetic nanoparticles bound to mitoxantrone. High-pressure liquid chromatography (HPLC) analyses after magnetic drug targeting showed an increasing concentration of the chemotherapeutic agent in the tumor region compared to regular systemic chemotherapy.
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