生物组织光学参数的校准模型及测量

在intralipid 墨水(ink)液体模型中,通过改变intralipid溶液和墨水的浓度就可以灵活地获得不同的光学参数。制作了一种可以长期重复使用的光学特性稳定的Si树脂模型,它是利用TiO2 粉末作为散射颗粒,同时加入C粉颗粒来改变模型的吸收特。为了验证intralipid 墨水液体模型制作中基于Mie散射理论的近似计算公式,利用多波长的时间分辨(TRS)方法对不同intralipid浓度的液体模型进行了测试。实际测量结果和Mie散射理论计算的误差在5%以内,这可能是由于所作用的intralipid溶液之间的差别造成的。利用频域的相位调制系统(PMD)对Si树脂模型进行了多间距测量,斜率的线性回归拟合结果显示了良好的线性度(R2>0.99),从而保证了光学参数测量结果的准确性。

Phantoms with Tissue-Like Optical Properties for Use in Near-Infrared Spectroscopy and Imaging

Intralipid was used for providing the scattering component in a liquid tissue phantom.By diluting intralipid we are able to change the scattering properties of our model.Addition of India ink changes the model absorption.In order to provide a stable and reproducible phantom,a pliable RTV silicon resin model was developed.Titanium oxide and carbon black powders were added to the resin to obtain tissue-like optical properties.Time-resolved spectroscopy(TRS) was employed to obtain experimental values for reduced scattering coefficient for intralipid-Ink solution at various wavelengths and we compare these values with those predicted by Mie theroy.The 5% difference between our results and the results from Mie thoery are attributed at least in part to a difference in Intralipid composition.Good linearity (R~2>0.99) is found for the lines used to defind the slope of AC component and phase.