Synthesis and Antibacterial Evaluation of Some Semicarbazides and 1,2,4‐Triazol‐5‐Ones Containing Thiophene Moieties |
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| Authors: | Monika Pitucha Alina Olender Monika Wujec Piotr Borowski Marek Mardarowicz |
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| Institution: | 1. Department of Organic Chemistry, Medical University, Staszica 6, 20‐081 Lublin, Poland;2. Chair and Department of Microbiology, Medical University, Chodzki 1, 20‐093 Lublin, Poland;3. Faculty of Chemistry, Maria Curie‐Sklodowska University, pl. M. Curie‐Sklodowskiej 3, 20‐031 Lublin, Poland;4. Analytical Laboratory, Maria Curie‐Sklodowska University, pl. M. Curie‐Sklodowskiej 3, 20‐031 Lublin, Poland |
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| Abstract: | In this study, some 3‐(thiophen‐2‐ylmethyl)‐4‐substituted‐4,5‐dihydro‐1H‐1,2,4‐triazol‐5‐one derivatives were synthesized by the cyclization reaction of 1‐(thiophen‐2‐ylacetyl)‐4‐substituted semicarbazide derivatives in alkaline medium or in the immediate reaction of thiophen‐2‐yl‐acetic acid hydrazide with isocyanates. The structures of all new compounds were confirmed by analytical and spectroscopic methods. Selected derivatives were evaluated in vitro against several species of aerobic bacteria. Some of them showed activity against S. pyogenes, P. aeruginosa and S. aureus. |
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| Keywords: | Semicarbazide 1 2 4‐Triazol‐5‐one Antibacterial activity |
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