A new thermally immobilized fluorinated stationary phase for RP‐HPLC |
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| Authors: | Liane Maldaner Isabel C S F Jardim |
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| Institution: | Institute of Chemistry, University of Campinas, Campinas, S?o Paulo, Brazil |
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| Abstract: | A new fluorinated stationary phase was prepared through thermal immobilization of poly(methyl‐3,3,3‐trifluoropropylsiloxane) onto 5 μm Kromasil silica particles. The best conditions of immobilization time and temperature were determined through a central composite design and response surface methodologies. Physical–chemical characterization using solid‐state 29Si NMR measurements, infrared spectroscopy and elemental analysis showed that the immobilization process was effective to promote a coating of the support that corresponds to a monolayer of polymer. The stationary phase presents selectivity for positional isomers and good peak shape for basic compounds. |
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| Keywords: | Experimental design Poly(methyl‐3 3 3‐trifluoropropylsiloxane) RP‐HPLC Stationary phases Thermal immobilization |
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