Synthesis of various 6-substituted 1,4,5,6-tetrahydropyridazines by substitution of a 1,4,5,6-tetrahydro-6-tosylhydrazinopyridazines |
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Authors: | Shunya Morita Jun-ichi Matsuo |
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Institution: | Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan |
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Abstract: | 1,4,5,6-Tetrahydro-1-tosyl-6-tosylhydrazinopyridazines were prepared by reaction of a 1,4-ketoaldehyde with two equivalents of tosylhydrazine. Thus-obtained hydropyridazines were utilized as a substrate for synthesis of various 1,4,5,6-tetrahydropyridazine derivatives by activation with a Lewis acid, and various nucleophiles reacted to give the corresponding 6-substituted 1,4,5,6-tetrahydropyridazine derivatives. Self-reaction of a 1,4,5,6-tetrahydro-6-tosylhydrazinopyridazine in the presence of 0.5 equivalent of titanium tetrachloride gave a 1,4,5,6-tetrahydropyridazine bearing a pyrrole ring at the 6-position. |
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Keywords: | Hydropyridazine Tosylhydrazone 1 4-Ketoaldehyde Lewis acid Self-reaction |
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