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Ullmann CO coupling of sterically hindered secondary alcohols using excess amount of strongly coordinating monodentate ligands
Authors:Hayato Sugata  Tetsu Tsubogo  Yoshitaka Kino  Hiromi Uchiro
Institution:1. Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan;2. Division of Fusion of Regenerative Medicine with DDS, Research Institute for Science and Technology (RIST), Tokyo University of Science, Japan
Abstract:A new effective copper catalyzed C/>O coupling reaction using excess amount of strongly coordinating monodentate ligands was successfully developed. Among the DMAP-type monodentate ligands, 4-pyrrolidinopyridine afforded the best results. The developed reaction is widely applicable for the synthesis of various hindered or acyclic secondary alkyl-aryl ethers. In this study, a novel and remarkable acceleration of the coupling reaction using excess amount of monodentate ligands was discovered.</td>
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Keywords:Copper catalyzed  Monodentate ligand  Alkyl aryl ether  Aliphatic alcohol
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