One-pot synthesis of tertiary alkyl fluorides from methyl oxalates by radical deoxyfluorination under photoredox catalysis |
| |
Authors: | Julien Brioche |
| |
Institution: | Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA, 76000 Rouen, France |
| |
Abstract: | Tertiary alkyl fluorides have been prepared from methyl oxalates derived from tertiary alcohols by a sequential one-pot hydrolysis/photoredox catalyzed radical deoxyfluorination sequence. The reaction operates under mild conditions and tolerates a wide range of functional groups. This method provides an alternative approach to ionic deoxyfluorination transformations for the incorporation of Carbone–Fluorine quaternary centers into organic molecules. |
| |
Keywords: | Radical fluorinarion Photoredox catalysis Deoxyfluorinarion Tertiary alkyl fluorides |
本文献已被 ScienceDirect 等数据库收录! |