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A new route to synthesis of substituted pyrazoles through oxidative [3+2] cycloaddition of electron deficient alkenes and diazocarbonyl compounds |
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| Authors: | J Paul Raj D Gangaprasad K Karthikeyan R Rengasamy M Kesavan M Venkateswarulu M Vajjiravel J Elangovan |
| Institution: | 1. Department of Chemistry, B. S. Abdur Rahman Crescent Institute of Science & Technology, Seethakathi Estate, Vandalur, Chennai 600048, India;2. Department of Chemistry, Rajah Serfoji Government College, Thanjavur, Tamil Nadu 613005, India;3. Interdisplinary Institute of Indian System of Medicine (IIISM), SRM Institute of Science and Technology, Kattankulathur, 603203, India;4. School of Basic Sciences, Indian Institute of Technology Mandi, Himachal Pradesh 17500, India |
| Abstract: | A collection of 3,5-disubstituted pyrazoles are constructed by the oxidative 3+2] cycloaddition of electron deficient terminal olefins with α-diazoesters and amides in the presence of Oxone and cetyltrimethyl ammonium bromide. The highlights of this protocol are; (i) shorter reaction time (ii) moderate to excellent yield (iii) good regioselectivity. |
| Keywords: | Oxidative [3+2] cycloaddition Diazo-olefin Phase transfer catalyst Transition metal free |
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