The 2-acetylthioethyl ester group: A versatile protective group for P-OH-groups |
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| Authors: | Jens C. Markwart Frederik R. Wurm |
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| Affiliation: | 1. Max-Planck-Institut für Polymerforschung (MPIP), Ackermannweg 10, 55128, Mainz, Germany;2. Graduate School Materials Science in Mainz, Staudinger Weg 9, 55128, Mainz, Germany |
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| Abstract: | ![]()
Phosphodiesters are bridging elements in nucleic acids. In nature and synthesis, their negative charge protects them from hydrolysis and controls their solubility profile. RNA is a promising material for gene technology but cellular uptake is low due to negative charges. Synthetic oligonucleotides were delivered into cells by a prodrug approach relying on the enzymatic release of the polyphosphodiester oligonucleotides. In synthetic chemistry, a protective group for the P | |
| Keywords: | Polyphosphoester Protective group ADMET Adhesive Phosphorus |
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