Highly enantioselective aza-henry reaction of ketimines catalyzed by a chiral bifunctional thiourea-tertiary amine derived from quinine |
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Authors: | Yanhong Fang Ning Lu Zhonglin Wei Jungang Cao Dapeng Liang Yingjie Lin Haifeng Duan |
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Institution: | Department of Organic Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China |
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Abstract: | We have developed a highly enantioselective aza-Henry reaction of aryl α-ketoester-derived N-Ts ketimines with a wide range of substrate scope by a simpler bifunctional thiourea-tertiary amine catalyst derived from quinine. A variety of ketimines were investigated and corresponding products were obtained in excellent yields (up to 99% yield) with excellent enatioselectivities (up to 99% ee). |
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Keywords: | Bifunctional Thiourea-tertiary amine Quinine Aza-henry reaction Ketimines |
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