Efficient and facile strategy to substituted 2-aminothiazoles via ring opening of α-nitroepoxides |
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| Authors: | Yue Zhu Qilin Wang Haofan Luo Guolin Zhang Yongping Yu |
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| Institution: | Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China |
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| Abstract: | A novel and efficient reaction has been developed to synthesize a set of substituted 2-aminothiazoles from α-nitroepoxides and ammonium thiocyanate. This reaction could proceed smoothly at mild condition, to afford products for a wide range of substrates with good to excellent yields. A possible mechanism has also been proposed. |
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| Keywords: | 2-Aminothiazoles α-Nitroepoxides Ammonium thiocyanate Facile synthesis |
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