Termination of Mn(III)-based oxidative cyclizations by trapping with azide |
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| Authors: | Snider Barry B Duvall Jeremy R |
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| Affiliation: | Department of Chemistry, MS 015, Brandeis University, Waltham, MA 02454-9110, USA. snider@brandeis.edu |
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| Abstract: | The radicals formed in Mn(III)-based oxidative free-radical cyclizations of beta-keto esters and malonate esters can be trapped with sodium azide and Mn(III) to give cyclic and bicyclic azides in 30-80% yield. Reduction of the azide gives bi- and tricyclic lactams. [reaction: see text] |
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