Catalytic asymmetric synthesis of glutamate analogues |
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Authors: | Burkhart David J McKenzie Andrew R Nelson Jared K Myers Katherine I Zhao Xue Magnusson Kathy R Natale Nicholas R |
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Institution: | Department of Chemistry, University of Idaho, 301 Renfrew Hall, Moscow, ID 83844-2343, USA. |
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Abstract: | Utilizing our lateral metalation coupled with Jacobsen's catalytic asymmetric amino nitrile synthesis, we have demonstrated the ability to synthesize isoxazole-containing amino acid glutamate analogues in high yield and high enantiomeric excesses. Chiral centers alpha or beta at the C-5 position do not detract from diastereoselectivity of the Jacobsen-Strecker reaction. reaction: see text] |
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