SN2 vs. E2 on quaternary centres: an application to the synthesis of enantiopure beta2,2-amino acids |
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| Authors: | Avenoza Alberto Busto Jesús H Corzana Francisco Jiménez-Osés Gonzalo Peregrina Jesús M |
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| Institution: | Departamento de Química, Universidad de La Rioja, Grupo de Síntesis Química de La Rioja, U.A.-C.S.I.C., E-26006 Logro?o, Spain. alberto.avenoza@dq.unirioja.es |
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| Abstract: | S(N)2 and E2 competing reactions in cyclic sulfamidates can be modulated by the change of an amide group to an ester group attached to the quaternary carbon activated for the nucleophilic attack, allowing an easy approach to enantiopure alpha,alpha-disubstituted beta-amino acids. |
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