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Oxalic acid as a catalyst for efficient synthesis of bis-(indolyl)methanes,and 14-aryl- 14H-dibenzo[a,j]xanthenes in water
作者姓名:Nagnnath D. Kokare  ;Jaiprakash N. Sangshetti  ;Devanand B. Shinde
作者单位:Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431004 lMsl. India;New Drug Discovery, Wockhardt Research Centre, Aurangabad 431210(MS). India
基金项目:The authors are thankful to Head, Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431004 (MS), India for providing laboratory facility.
摘    要:A simple, efficient, and environment benign route was developed for the preparation of bis-(indolyl)methanes and 14-aryl-14H- dibenzoaj]xanthenes from condensation of various aromatic aldehydes or ketones with indole, and 2-naphthol, respectively, using oxalic acid catalyst in aqueous medium. Use of cheap and easily available catalyst, better yields and simple reaction protocol are the advantages of the present method.

关 键 词:草酸  甲烷  14-芳基-14H-氧芴  氧杂蒽  乙醛

Oxalic acid as a catalyst for efficient synthesis of bis-(indolyl)methanes,and 14-aryl-14H-dibenzo[a,j]xanthenes in water
Nagnnath D. Kokare,;Jaiprakash N. Sangshetti,;Devanand B. Shinde.Oxalic acid as a catalyst for efficient synthesis of bis-(indolyl)methanes,and 14-aryl-14H-dibenzo[a,j]xanthenes in water[J].Chinese Chemical Letters,2008,19(10):1186-1189.
Authors:Nagnnath D Kokare Jaiprakash N Sangshetti Devanand B Shinde
Institution:Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431004 lMsl. India;New Drug Discovery, Wockhardt Research Centre, Aurangabad 431210(MS). India
Abstract:A simple,efficient,and environment benign route was developed for the preparation of bis-(indolyl)methanes and 14-aryl-14H- dibenzoa,j]xanthenes from condensation of various aromatic aldehydes or ketones with indole,and 2-naphthol,respectively,using oxalic acid catalyst in aqueous medium.Use of cheap and easily available catalyst,better yields and simple reaction protocol are the advantages of the present method.
Keywords:Oxalic acid  Bis-(indolyl)methanes  14-Aryl-14H-dibenzo[a  j]xanthenes  Aldehydes
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