分析测试新成果(169~178)液相色谱-电喷雾离子阱质谱联用分析毛发中6种合成大麻素

作为第三代毒品中重要的一类, 合成大麻素类新精神活性物质被当做大麻的替代品而滥用严重, 已经引起社会的广泛关注.基于液相色谱-质谱联用技术的优势与特点, 建立了毛发样品中JWH-073、MAM-2201、JWH-015、JWH-203、JWH-018、JWH-007等6种合成大麻素类新精神活性物质的液相色谱-电喷雾离子阱质谱联用定性、定量分析方法.毛发样品经剪段、清洗后, 用甲醇超声提取, 进样分析, 6种目标化合物的质量浓度在3~200 ng/mg之间具有良好的线性关系, 相关系数大于0.990 1, 定量限小于3 ng/mg, 检出限小于1 ng/mg, 精密度小于9.99%, 提取回收率为90.69%~97.88%.建立的方法样品处理简便、检测灵敏度高、专属性强、重现性好, 可为打击新型毒品违法犯罪活动, 遏制新型毒品蔓延提供科学理论依据与技术支持, 具有重要的现实意义.

Simultaneous Analysis of Six Synthetic Cannabinoids in Hair by Liquid Chromatography-Electrospray Ion Trap Mass Spectrometry

As the substitutes of cannabis, synthetic cannabinoids are widely abused as the typical category of the 3rd abused drugs, which has aroused widespread concern of the society. The harm of abusing of synthetic cannabinoids are increasing day by day. In this paper, an approach for the simultaneous analysis of new psychoactive substances in hair by liquid chromatography-electrospray ion trap mass spectrometry has been established and applied to the qualitative and quantitative analysis of 6 synthetic cannabinoids, including JWH-073, MAM-2201, JWH-015, JWH-203, JWH-018 and JWH-007. The hair sample was cut and cleaned, and then ultrasonic extracted with methanol. Linear calibration curves showed a good linearity in the range 3~200 ng/mg, with coefficients of greater than 0.990 1, the limit of quantification was less than 3 ng/mg, the limit of detection was less than 1 ng/mg, the precisions were less than 9.99%, and the recoveries from spiked hair samples varied from 90.69% to 97.88%. The experimental results showed that the analytical strategy could provide scientific basis and evidence support for the identification, detection and litigation of drug-related cases.