| 新型喹唑啉类酪氨酸激酶化学抑制剂的设计与合成 |
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| 引用本文： | 张向阳,刘章琴,陈元伟. 新型喹唑啉类酪氨酸激酶化学抑制剂的设计与合成[J]. 合成化学, 2009, 17(2) |
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| 作者姓名： | 张向阳 刘章琴 陈元伟 |
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| 作者单位： | 中国科学院,成都有机化学研究所,不对称合成与手性技术四川省重点实验室,四川,成都,610041;中国科学院,研究生院,北京,100049;中国科学院,成都有机化学研究所,不对称合成与手性技术四川省重点实验室,四川,成都,610041 |
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| 基金项目： | 中国科学院"百人计划"项目 |
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| 摘 要： | 以6-氨基藜芦酸和醋酸甲脒为起始原料,合成了一系列4-位具有不同芳胺基团,6,7-位引入不同取代基的新型喹唑啉类酪氨酸激酶化学抑制剂,其结构经1H NMR表征.
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| 关 键 词： | 喹唑啉 氨基藜芦酸 酪氨酸激酶 药物合成 |
Design and Synthesis of Novel Quinazoline Derivatives as Tyrosine Kinase Chemical Inhibitors |
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| ZHANG Xiang-yang,LIU Zhang-qin,CHEN Yuan-wei. Design and Synthesis of Novel Quinazoline Derivatives as Tyrosine Kinase Chemical Inhibitors[J]. Chinese Journal of Synthetic Chemistry, 2009, 17(2) |
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| Authors: | ZHANG Xiang-yang LIU Zhang-qin CHEN Yuan-wei |
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| Affiliation: | 1.Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis;Chengdu Institute of Organic Chemistry;Chinese Academy of Sciences;Chengdu 610041 China;2.Graduate University of Chinese Academy of Sciences;Beijing 100049;China |
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| Abstract: | Novel quinazoline derivatives with aromatic amino substitution at the position 4,different substituents introduced at the position 6 and 7,as tyrosine kinase chemical inhibitors,were synthesized from 6-aminoveratric acid and formamidine acetate.The structures were confirmed by 1H NMR. |
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| Keywords: | quinazoline aminoveratric acid tyrosine kinase drug synthesis |
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