| 异烟肼乳酸-乙醇酸共聚物磁性微球的制备和体外释放 |
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| 引用本文： | 周恒,李艳,黄华. 异烟肼乳酸-乙醇酸共聚物磁性微球的制备和体外释放[J]. 光谱实验室, 2010, 27(3): 892-895 |
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| 作者姓名： | 周恒 李艳 黄华 |
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| 作者单位： | 重庆医科大学药学院药剂教研室193#,重庆市渝中区医学院路1号,400016 |
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| 基金项目： | 重庆市卫生局重点课题，中国博士后科学基金 |
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| 摘 要： | 采用化学共沉法制备磁性Fe3O4纳米粒,再采用W/O/W复乳-溶剂挥干法制备异烟肼乳酸-乙醇酸共聚物[Poly(lactide-co-glycolide),PLGA]磁性微球(INH-PLGA-MMS);电镜考察INH-PLGA-MMS形态、激光粒径分析仪考察粒径分布、磁场计测定磁感应强度、高效液相色谱法(HPLC)测定包封率、载药量及其释放度。结果表明,W/O/W复乳-溶剂挥干法制得的INH-PLGA-MMS外观圆整、表面光滑,平均粒径为3.02μm,磁感应强度为11.403emu/g,平均包封率为62.52%,平均载药量为9.21%,体外释放表明该制剂具有明显的缓释功能,外加振荡磁场可以增加磁性微球中药物的释放。
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| 关 键 词： | 异烟肼 异烟肼乳酸-乙醇酸共聚物 磁性微球 振荡磁场 |
Study on the Preparation and in Vitro Release of Isoniazid Sulfate-Loaded PLGA Magnetic Microsphere |
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| ZHOU Heng,LI Yan,HUANG Hua. Study on the Preparation and in Vitro Release of Isoniazid Sulfate-Loaded PLGA Magnetic Microsphere[J]. Chinese Journal of Spectroscopy Laboratory, 2010, 27(3): 892-895 |
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| Authors: | ZHOU Heng LI Yan HUANG Hua |
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| Affiliation: | (College of Pharmacy,Chongqing Medical University,Chongqing 400016,P.R.China) |
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| Abstract: | The magnetic nanospheres were prepared by chemical coprecipitation and then the isoniazid sulfate-loaded PLGA magnetic microspheres （INH-PLGA-MMS） were prepared by W/O/W double-emulsion/solvent evaporation method,and the characteristics were studied.The INH-PLGA-MMS were round and smooth with the average particle size 3.02μm,encapsulation efficiency 62.52%,drug loading 9.21%,intensity of magnetic response 11.403emu/g.The release results in vitro show that the INH-PLGA-MMS have the character of sustained-release,and the oscillating magnetic fields could promote the drug release. |
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| Keywords: | Isoniazid PLGA Magnetic Microspheres Oscillating Magnetic Fields |
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