| 温度敏感聚(N-异丙基丙烯酰胺)/聚(乙烯醇)水凝胶的制备及性能研究 |
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| 引用本文： | 张先正,卓仁禧.温度敏感聚(N-异丙基丙烯酰胺)/聚(乙烯醇)水凝胶的制备及性能研究[J].高等学校化学学报,2000,21(11):1776-1778. |
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| 作者姓名： | 张先正 卓仁禧 |
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| 作者单位： | 教育部生物医用高分子材料重点实验室, 武汉大学化学系, 武汉 430072 |
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| 摘 要： | 聚 (N -异丙基丙烯酰胺 ) (PNIPA)水凝胶具有温度敏感性 ,其在 33℃左右有一个相转变温度或较低临界溶解温度 (L CST) 1,2 ] .当外界温度低于 LCST时 ,PNIPA水凝胶吸水溶胀 ;而当外界温度高于L CST时 ,PNIPA水凝胶剧烈收缩失水 ,发生相分离 .这种相分离特性应用于药物的控制释放 3] .固定化酶4 ] 和循环吸收剂 5] 等领域 .然而 ,通常的 PNIPA水凝胶是通过化学键交联而成的三维网络聚合物 ,很难发生解体或进行生物降解 ,其在某些特定场合 (如药物的体内释放等 )受到一定限制 .聚乙烯醇 (PVA)的亲水性和生物相容性较好 ,是…
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| 关 键 词： | 温度敏感 冷冻-融溶 物理交联 水凝胶 |
| 收稿时间： | 1999-05-27 |
Preparation and Characterization of Temperature-sensitive Poly(N-isopropylacrylamide)/Poly(vinyl alcohlo) Hydrogels |
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| ZHANG Xian-Zheng,ZHUO Ren-Xi.Preparation and Characterization of Temperature-sensitive Poly(N-isopropylacrylamide)/Poly(vinyl alcohlo) Hydrogels[J].Chemical Research In Chinese Universities,2000,21(11):1776-1778. |
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| Authors: | ZHANG Xian-Zheng ZHUO Ren-Xi |
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| Institution: | Key Laboratory of Biomedical Polymer Materials of the Educational Ministry, Department of Chemistry, Wuhan University, Wuhan 430072, China |
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| Abstract: | Poly( N isopropylacrylamide)/poly(vinyl alcohol)(PNV) hydrogels were prepared by repetitive freezing and thawing. This kind of hydrogels was formed through physical crosslinking, i.e. hydrogen bonds during the freezing process. The swelling ratio and deswelling/reswelling kinetics were measured gravimetrically and this novel hydrogel exhibits a temperature sensitivity. This hydrogel may be useful both in biomedical and biotechnological fields. |
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| Keywords: | Temperature sensitive Freezing and thawing Physical crosslinking Hydrogel |
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