A solid phospholipid-bile salts-mixed micelles based on the fast dissolving oral films to improve the oral bioavailability of poorly water-soluble drugs |
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Authors: | Lv Qing-yuan Li Xian-yi Shen Bao-de Dai Ling Xu He Shen Cheng-ying Yuan Hai-long Han Jin |
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Institution: | 1. Medicinal Chemistry, Faculty of Medicine, School of Pharmacy, Institute for Drug Research, Hebrew University of Jerusalem, 91120, Jerusalem, Israel 2. Columbus NanoWorks Inc., 1507 Chambers Dr., Columbus, OH, 43212, USA 3. Institute for Drug Research, School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel 4. Jerusalem College of Engineering (JCE), Jerusalem, Israel 5. Center for Nanotechnology and the Grass Center for Drug Design and Synthesis, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel
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Abstract: | Magnetic iron oxide nanoparticles surface covered with oleic acid layer followed by a second layer of hydrophobized oxidized dextran aldehyde were prepared and tested for physico-chemical properties and ligand- and cell-specific binding. It was demonstrated that oleic acid–iron oxide nanoparticles coated with an additional layer of hydrophobized oxidized dextran were dispersible in buffer solutions and possess surface aldehyde active groups available for further binding of ligands or markers via imine or amine bond formation. Hydrophobized dextrans were synthesized by periodate oxidation and conjugation of various alkanamines to oxidized dextran by imination. Physico-chemical properties, as separation using magnetic field, magnetite concentration, and particle diameter, of the prepared magnetic samples are reported. The biotin-binding protein, neutravidin, was coupled to the particle surface by a simple reductive amination procedure. The particles were used for specific cell separation with high specificity. |
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