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Novel Schiff base ligands derived from Cinchona alkaloids for Cu(II)-catalyzed asymmetric Henry reaction |
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| Authors: | Yu WeiLin Yao Bangle ZhangWei He Shengyong Zhang |
| Institution: | a Department of Chemistry, School of Pharmacy, Fourth Military Medical University, Shaanxi Province, Xi’an 710032, PR China b Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Shaanxi Province, Xi’an 710032, PR China |
| Abstract: | A new series of Schiff bases derived from Cinchona alkaloids were developed as chiral ligands for the copper(II)-catalyzed asymmetric Henry reaction. The optimized catalyst can promote the Henry reaction of both aromatic and aliphatic aldehydes with nitromethane or nitroethane. Those reactions can afford the chiral β-nitro alcohol adducts with high enantioselectivities. |
| Keywords: | Henry reaction Schiff base ligands Copper complexes Asymmetric catalysis Cinchona alkaloids |
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