| A MODEL STUDY ON MODE OF BONDING OF CISPLATIN WITH DNA |
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| 作者姓名： | 唐雯霞 曲筠 张士勇 朱龙根 戴安邦 |
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| 作者单位： | Coordination Chemistry Research Institute，Nanjing University，Coordination Chemistry Research Institute，Nanjing University，Coordination Chemistry Research Institute，Nanjing University，Coordination Chemistry Research Institute，Nanjing University，Coordination Chemistry Research Institute，Nanjing University |
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| 基金项目： | This research was supported by the Science Foundation, Academia Sinica. |
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| 摘 要： | The interaction of cis-[Pt(NK_3)_2Cl_2] with nucleosides, as constituents of DNA, was studled by spectrophotometric, ~(13)C NMR and CNDO/2 methods. The apparent stability constants of the complexes formed and the initial rate of formation were determined. The sites of binding of nucleoside (or nucleotide) with Cisplatin were ascertained and the electronic structure of the model coordination compounds of Cisplatin and guanine was calculated by MO approach. On the basis of the obtained results, the mechanism of the antitumour action of Cisplatin was discussed, and a new possible mode of bonding of Cisplatin with DNA was proposed.
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