Transition metal coordination compounds of an antiobesity serotoninergic ligand: spectroscopic characterization and adipogenesis activity |
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| Authors: | Milton Enrique Londoño-Lemos Pablo Martínez-Bulit Horacio López-Sandoval Isabel Gracia-Mora Francisco Sánchez-Bartez Tannya Castro-Jiménez Angélica María Duarte-Hernández Angelina Flores-Parra Rosalinda Contreras Norah Barba-Behrens |
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| Affiliation: | 1.Departamento de Química Inorgánica, Facultad de Química,Universidad Nacional Autónoma de México, C.U,Coyoacán,Mexico;2.Departamento de Química,Cinvestav,Ciudad de México,Mexico;3.Unidad de Experimentación Animal, Facultad de Química,Universidad Nacional Autónoma de México, C.U,Coyoacán,Mexico;4.Vicerrectoría de Investigaciones,Universidad Manuela Beltrán,Bogotá D.C,Colombia;5.Laboratorio de Biología Molecular e Inmunología de Arbovirus, Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala,Universidad Nacional Autónoma de México,Tlalnepantla de Baz,Mexico |
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| Abstract: | Coordination compounds of cobalt(II), nickel(II), copper(II) and zinc(II) with L-5-hydroxytryptophan (L-5-HTP) were synthesized and characterized by elemental analysis, IR and UV–Vis-NIR spectroscopy, mass spectrometry and thermogravimetric analysis. The X-ray structure of the pure enantiomer ligand (L-5-HTP) was obtained. The ligand coordinates to the metal ions in an unidentate mode, where the donor atom is the oxygen from the carboxylic group. The intramolecular H-bond, N1H···O2, observed in the X-ray crystal structure of the free L-5-HTP, remains as a stabilization factor in all of the coordination compounds. Two types of geometries were adopted by the metal centers: tetrahedral and octahedral. In vitro antiadipogenic studies of the coordination compounds showed that the tetrahedral cobalt(II) and copper(II) complexes presented potential antiobesity properties. |
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