A glucosamine-dipicolylamine conjugate of 99mTc(I) and 186Re(I) for use in imaging and therapy |
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| Authors: | Storr Tim Fisher Cara L Mikata Yuji Yano Shigenobu Adam Michael J Orvig Chris |
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| Institution: | Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia V6T 2A3, Canada. |
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| Abstract: | The synthesis and metal complexation of a glucosamine-appended 2,2'-dipicolylamine ligand to the tricarbonyls of 99mTc and 186Re is described; the ligand was found to bind in a tridentate fashion with the glucosamine function remaining pendant, and the 99mTc complex was found to exhibit exceptional stability towards in vitro ligand exchange experiments. |
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