Stereocontrolled access to optically-enriched oxabispidines |
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| Authors: | Brice Heloise Gill Duncan M Goldie Laura Keegan Philip S Kerr William J Svensson Per H |
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| Institution: | Pharmaceutical Development, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough LE11 5RH, UK. |
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| Abstract: | A range of chiral, optically-enriched bicyclic oxabispidines were prepared from (S)-(-)-2,3-epoxypropylphthalimide using an efficient sequence featuring a stereocontrolled intramolecular Mannich reaction as the key transformation. |
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