CO2 gas induced drug release from pH-sensitive liposome to circumvent doxorubicin resistant cells |
| |
| Authors: | Liu Juan Ma Huili Wei Tuo Liang Xing-Jie |
| |
| Institution: | CAS Key Laboratory for Biological Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, 11 Beiyijie, Zhongguancun, Beijing 100190, China. |
| |
| Abstract: | A novel pH-sensitive liposome encapsulating doxorubicin was prepared by a NH(4)HCO(3) gradient method. The liposomes were able to release the drug at pH 5.0 by the production of CO(2) gas. More importantly, the drug-loaded liposome effectively circumvented the breast cancer cells resistant to doxorubicin. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
