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The first synthesis of 3-deoxyoripavine and its utilization in the preparation of 10-deoxyaporphines and cyprodime |
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| Authors: | Attila Sipos Antal Udvardy Attila C. Bényei Sándor Berényi | |
| Affiliation: | 1. Department of Pharmaceutical Chemistry, Medical and Health Science Centre, University of Debrecen, H-4010, Debrecen, Hungary 2. Department of Physical Chemistry, University of Debrecen, H-4010, Debrecen, Hungary 3. Department of Organic Chemistry, University of Debrecen, H-4010, Debrecen, Hungary |
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| Abstract: | The synthesis of 3-deoxyoripavine (7) was realized as a novel and promising intermediate towards the synthesis of the important class of dopaminergic and/or serotonergic 10-deoxyaporphines and the special pharmacological tool µ opioid antagonist cyprodime. Generally, the preparation of these valuable biologically active compounds was achieved in remarkable yields.  | |
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