| Abstract: | The inclusion complexations of β-cyclodextrin with four hyoscyamine drugs were investigated by microcalorimetric technique and 1HNMR. All the inclusion complexes were found to be 1:1 and their thermodynamic parameters of formation constant K, ΔG°, ΔH° and ΔS° were obtained. The 1HNMR spectra strongly suggested that the drug molecule is included in the hydrophobic cavity of β-cyclodextrin. The properties of binding force and effects of steric hindrance and chirality of the drugs on the inclusion complexation were also discussed. |
