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Synthesis and Biological Activity of α-Methylene-γ-butyrolactones
Authors:H M R Hoffmann  Jürgen Rabe
Abstract:α-Methylene-γ-butyrolactones dihydro-3-methylene-2(3H)furanones] constitute an important group of natural products and possess wide-ranging biological activities. Progress in the synthesis of the heterocycle and the classification of the synthetic methods are not only of practical interest, but also fundamentally important as a current example for the construction of an unusual 1,4-functionality distance and an α-substituted acrylic ester moiety which is susceptible to nucleophilic attack.
Keywords:α  -Methylene-γ  -butyrolactones  Butyrolactones  Lactones  Natural products
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