Phosphine-catalyzed construction of sulfur heterocycles |
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| Authors: | Gabillet Sandra Lecerclé Delphine Loreau Olivier Carboni Michael Dézard Sophie Gomis Jean-Marie Taran Frédéric |
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| Institution: | CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage, Gif sur Yvette F-91191, France. |
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| Abstract: | A simple and efficient method for constructing sulfur heterocycles was developed using a phosphine-catalyzed tandem umpolung addition and intramolecular cyclization of bifunctional sulfur pronucleophiles on arylpropiolates. The reaction offers a promising route to synthetically useful as well as biologically active heterocycles under neutral conditions. |
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