Cramér-Rao Bound Expressions for Parametric Estimation of Overlapping Peaks: Influence of Prior Knowledge |
| |
Authors: | S Cavassila S Deval C Huegen D van Ormondt D Graveron-Demilly |
| |
Institution: | a Lab. RMN, CNRS UMR 5012, UCB LYON I-CPE, 69622, Villeurbanne, France;b Applied Physics Department, Delft University of Technology, Delft, The Netherlands |
| |
Abstract: | We have derived analytical expressions of the Cramér-Rao lower bounds on spectral parameters for singlet, doublet, and triplet peaks in noise. We considered exponential damping (Lorentzian lineshape) and white Gaussian noise. The expressions, valid if a sufficiently large number of samples is used, were derived in the time domain for algebraic convenience. They enable one to judge the precision of any unbiased estimator as a function of the spectral and experimental parameters, which is useful for quantitation objectives and experimental design. The influence of constraints (chemical prior knowledge) on parameters of the peaks of doublets and triplets is demonstrated both analytically and numerically and the inherent benefits for quantitation are shown. Our expressions also enable analysis of spectra comprising many peaks. |
| |
Keywords: | MR spectroscopy quantitation error estimation Cramé r-Rao bounds prior knowledge |
本文献已被 ScienceDirect 等数据库收录! |
|