Novel Peak Assignments of in VivoC MRS in Human Brain at 1.5 T |
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Authors: | Stefan Blüml Jong-Hee Hwang Angel Moreno Brian D Ross |
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Institution: | a Huntington Medical Research Institutes, Pasadena, California, 91105;b Rudi Schulte Research Institute, Santa Barbara, California |
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Abstract: | 13C MRS studies at natural abundance and after intravenous 1-13C glucose infusion were performed on a 1.5-T clinical scanner in four subjects. Localization to the occipital cortex was achieved by a surface coil. In natural abundance spectra glucose C3β,5β, myo-inositol, glutamate C1,2,5, glutamine C1,2,5, N-acetyl-aspartate C1-4,C=O, creatine CH2, CH3, and CC=N, taurine C2,3, bicarbonate HCO−3 were identified. After glucose infusion 13C enrichment of glucose C1α,1β, glutamate C1-4, glutamine C1-4, aspartate C2,3, N-acetyl-aspartate C2,3, lactate C3, alanine C3, and HCO−3 were observed. The observation of 13C enrichment of resonances resonating at >150 ppm is an extension of previously published studies and will provide a more precise determination of metabolic rates and substrate decarboxylation in human brain. |
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Keywords: | proton decoupled 13C MRS glutamate glutamine glucose infusion tricarboxylic acid cycle |
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