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Highly Efficient Synthesis of Arylpyrrole Derivatives via Rh(III)‐Catalyzed Direct CH Arylation with Aryl Boronic Acids |
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| Authors: | Liang Wang Zhan Li Xing Qu Wangming Peng |
| Institution: | 1. Key Laboratory of Optoelectronic Chemical Materials and Devices, Ministry of Education, Jianghan University, Wuhan, Hubei 430056, China;2. School of Chemical and Enviromental Engineering, Jianghan University, Wuhan, Hubei 430056, China |
| Abstract: | An efficient and facile method for synthesis of 2‐arylpyrroles through Rh(III)‐catalyzed direct C? H arylation with pyrrole derivatives and aryl boronic acids has been developed. This reaction could proceed under mild reaction conditions and afford a series of 2‐arylated products in good to excellent yields. The gram‐scale experiment has been conducted to demonstrate the synthetic potential of this methodology. |
| Keywords: | rhodium‐catalysis C H arylation arylpyrrole derivatives aryl boronic acids |