Organocatalytic Oxidative Amidation of Aldehydes with Tetrazoles to Construct 2,5‐Diaryl 1,3,4‐Oxadiazoles |
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| Authors: | Jing Cao Liang Wang |
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| Affiliation: | School of Petrochemical Engineering, Changzhou University, Changzhou, Jiangsu 213164, China |
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| Abstract: | A practical and metal‐free oxidative amidation of aldehydes with tetrazoles into 1,3,4‐oxadiazoles has been developed by employing tetrabutylammonium iodide (TBAI) as catalyst and tert‐butyl hydroperoxide (TBHP) as oxidant. A wide range of 2,5‐disubstituted 1,3,4‐oxadiazoles can be conveniently generated in moderate to good yields. Gram‐scale reaction was also realized in this catalytic system. |
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| Keywords: | 1,3,4‐oxadiazoles oxidative amidation tetrazoles aldehydes organocatalysis |
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