One‐Pot Synthesis of Aliphatic Nitro Compounds by Michael/retro‐Claisen Fragmentation Domino Reaction |
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| Authors: | Wei Zhang Yanjing Wang Cuibing Bai Jialong Wen Naixing Wang |
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| Institution: | 1. Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China;2. College of Sciences, Beijing University of Chemical Technology, Beijing 100029, China |
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| Abstract: | A novel and concise method for the construction of γ‐nitro ketones and 1,3‐dinitro compounds with chemoselective acyl transfer has been presented under basic conditions via one‐pot reactions. These reactions feature high atom‐ and step‐economic possess, mild condition and simple operation for one‐pot synthesis of aliphatic nitro compounds. This protocol provides the products in good yields. The possible reaction mechanism has also been proposed. |
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| Keywords: | γ ‐nitro ketones 1 3‐dinitro compounds chemoselective acyl transfer domino reaction atom‐ and step‐economies |
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