Synthesis and Acid‐Catalyzed Cyclization of 2‐Alkenylstilbenes: a New Approach to the Substituted Indenes |
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| Authors: | Wei Ding Xiaoxin Shi Xia Lu |
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| Institution: | Department of Pharmaceutical Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China |
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| Abstract: | A base‐catalyzed ring‐opening of 1‐benzylisochromans 1 firstly produced 2‐alkenylstilbenes 2 , which then underwent a mild acid‐catalyzed intramolecular cyclization to furnish 1,2‐disubstituted indenes 3 in high yields. Subsequently, a base‐catalyzed isomerization of the 1,2‐disubstituted indenes 3 afforded the more stable 2,3‐disubstituted indenes 4 in almost quantitative yields. |
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| Keywords: | isochroman stilbene indene cyclization ring‐opening synthetic methodology |
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