Bromine/para‐Toluenesulfonic Acid‐Catalyzed Synthesis of 3,3‐Bis(indole‐3‐yl)indoline‐2‐
(1H)‐ones by Condensing Indoles with Isatins |
| |
| Authors: | Wenzhong Huang Lingli Nang Xiangguang Li Lin Yuan Yinhai Ma Deqiang Liang |
| |
| Affiliation: | Department of Chemistry, Kunming University, Kunming, Yunnan 650214, China |
| |
| Abstract: | Under the catalysis of only 3 mol% of Br2 at room temperature, indoles reacted rapidly with isatins to form biologically important 3,3‐bis(indole‐3‐yl)indoline‐2‐(1H)‐ones with high efficiency and wide substrate scope. Moreover, we demonstrated that p‐toluenesulfonic acid (TsOH) could serve as a surrogate to catalyze this transformation. |
| |
| Keywords: | homogeneous catalysis bromine effect indole functionalization C C coupling alkylation |
|
|
