Optimization of iodine determination according to Sch?nigerAnalytical chemistry with 1,3-dibromo-5,5-dimethylhydantoin (DBH)a Part 1, Oxygen flask combustion Part 7 [1, 2] |
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Authors: | Manfred Hilp |
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Affiliation: | (1) Institut für Pharmazeutische Chemie der Philipps-Universit?t, Marbacher Weg 6, D-35032 Marburg e-mail: Hilp@pharmazie.uni-marburg.de, XX |
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Abstract: | The method of iodine determination in organic compounds according to Sch?niger [3, 4] was improved by using an alkaline absorption solution of DBH. In contrast to elemental bromine DBH is a stable and easy to handle crystalline compound. For the removal of the excess of DBH 5-sulfosalicylic acid (C7H6O6S × 2H2O [5965-83-3]) [5] is more suitable than formic acid [64-18-6]. Assays for the determination of 2-iodobenzoic acid in the range from 1 to 25 mg iodine are described. 32 organic iodine compounds, mostly x-ray contrast media, could be analyzed with a percentage relative standard deviation of about 0.2%. Received: 10 March 1997 / Accepted: 15 May 1997 |
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