Selenium-catalyzed halolactonization: nucleophilic activation of electrophilic halogenating reagents |
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Authors: | Mellegaard Shelli R Tunge Jon A |
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Institution: | Department of Chemistry, University of Kansas, Lawrence, KS 66045, USA. |
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Abstract: | Diphenyl diselenide catalyzes the halolactonization of unsaturated acids with N-halosuccinimides under mild conditions. The diselenide not only accelerates the reactions, but in some cases affords regiocontrol in favor of gamma-lactone products. Experiments show that the regioselectivity in favor of gamma-lactones is a result of kinetic rather than thermodynamic control. |
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