Structure and reactivity of 2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one |
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| Authors: | L. D. Smirnov S. V. Nikitin A. I. Chernyshev A. A. Sorokin V. P. Lezina V. G. Zabrodnyaya M. M. Kaganskii |
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| Affiliation: | (1) All-Union Scientific Center for Safety in Dealing with Biologically Active Compounds, 142450 Kupavna, Moscow Oblast;(2) Scientific-Research Institute of Pharmacology, Russian Academy of Medical Sciences, USSR |
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| Abstract: | It has been shown that the alkylation of 2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one takes place at the oxygen atom, but electrophilic substitution takes place mainly at position 8 of the molecule (the ortho position relative to the hydroxy group).Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1660–1666, December, 1992. |
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