Rhodium catalyzed synthesis of isoindolinones via C-H activation of N-benzoylsulfonamides |
| |
Authors: | Chen Zhu John R. Falck |
| |
Affiliation: | Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9038, USA |
| |
Abstract: | An efficient approach to a wide range of isoindolinones, including 3-monosubstituted and 3,3-disubstituted isoindolinones, from the annulation of N-benzoylsulfonamides with olefins and diazoacetate has been developed. The transformation is broadly compatible with both terminal and internal olefins. Moreover, diazoacetate is for the first time incorporated into an amide-directed C-H functionalization reaction. Specifically, the rhodium complex [{RhCl2Cp*}2] enables the in situ dimerization of diazoacetate in addition to its role in catalyzing C-H functionalization/cross-coupling. |
| |
Keywords: | N-Benzoylsulfonamide C-H activation Diazoacetate Isoindolinone Rhodium catalysis |
本文献已被 ScienceDirect 等数据库收录! |
|