Design of an optical sensor for indirect determination of isoniazid |
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Authors: | Safavi Afsaneh Bagheri Mozhgan |
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Affiliation: | Department of Chemistry, Faculty of Sciences, Shiraz University, Shiraz 71454, Iran. |
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Abstract: | The characterization of an optical sensor membrane is described for indirect determination of isoniazid. The sensing membrane was consisted of immobilized 3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine (PDT) on a triacetylcellulose membrane. The procedure is based on the reaction of Fe(III) with isoniazid in the presence of PDT. Fe(III) is reduced by isoniazid to Fe(II) which forms a complex with PDT. The complex shows an absorption maximum at 558nm. By measuring the absorbance of the complex at this wavelength, isoniazid can be determined in the range of 0.62-6.15mugmL(-1). This method was applied to the determination of isoniazid in pharmaceutical formulation and enabled the determination of isoniazid in microgram quantities. |
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Keywords: | Isoniazid determination Optical sensor |
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