Alkynyltrifluoroborates as versatile tools in organic synthesis: a new route to spiroketals |
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| Authors: | Doubský Jan Streinz Ludvík Saman David Zedník Jirí Koutek Bohumír |
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| Affiliation: | Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10 Prague 6, Czech Republic. |
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| Abstract: | [reaction: see text] A simple and efficient two-step approach to spiroketals is described. Key steps include the preparation of functionalized hydroxyl alpha-alkynones by ring-opening reactions of lactones with lithium alkynyltrifluoroborates followed by a palladium-catalyzed hydrogenation/spirocyclization of the prespiroketal intermediate. |
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