A concise formal total synthesis of mappicine and nothapodytine B via an intramolecular hetero Diels-Alder reaction |
| |
Authors: | Toyota M Komori C Ihara M |
| |
Affiliation: | Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai, 980-8578, Japan. |
| |
Abstract: | A six-step formal total synthesis of a natural alkaloid, mappicine (3), has been achieved. The highlight of our synthetic strategy is an intramolecular hetero Diels-Alder reaction that was used for the construction of the CD ring system of mappicine (3). In addition, it was demonstrated that the Sonogashira coupling reaction of 2-chloro-3-hydroxymethylquinoline (8c) with trimethylsilylacetylene proceeded at room temperature in excellent yield. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|