Development of a quality evaluation system for Panax quinquefolium. L based on HPLC chromatographic fingerprinting of seven major ginsenosides |
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| Authors: | Junhui Chen Mingyong Xie Zhihong Fu Frank Sen-Chun Lee Xiaoru Wang |
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| Affiliation: | aKey Laboratory of Food Science of Ministry of Education, Nanchang University, Nanchang, Jiangxi 330047, China;bCollege of Chemistry and Chemical Engineering, Ocean University of China, Qingdao, Shandong 266003, China;cQingDao Key Lab on Analytical Technology Development and Standardization of Chinese Medicines, First Institute Oceanography of SOA, Qingdao, Shandong 266061, China |
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| Abstract: | A HPLC fingerprinting method based on the distribution and contents of seven major ginsenosides has been developed for the quality evaluation of Panax quinquefolium. L roots cultivated in China, Singapore and Canada. The method is ideally suited for the fingerprinting of P. quinquefolium. L samples or its derived products for sample authentication or quality control, e.g. pharmaceutical stability studies. Different extraction methods have been evaluated and a protocol established to maximize the gensinosides yields in routine operations. Hierarchical clustering analysis of the fingerprints demonstrates that the distribution and contents of ginsenosides in P. quinquefolium. L root vary depending on geographic location; and the quality of Jilin-cultivated P. quinquefolium. L roots is similar in composition to Canada-cultivated ones, which are generally considered among the best quality in P. quinquefolium. L. |
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| Keywords: | High-Performance Liquid Chromatography Panax quinquefolium. L Ginsenoside Quality evaluation system Hierarchical clustering analysis |
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