| Kinetic Studies on Ligand Substitution Reactions of Metallothioneins with DTPA and EDTA |
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| 引用本文： | Li Rongchang,Gao Fei and Wang Kui (Department of Inorganic Chemistry,Beijmg Medical University,Beijing). Kinetic Studies on Ligand Substitution Reactions of Metallothioneins with DTPA and EDTA[J]. 高等学校化学研究, 1990, 0(1) |
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| 作者姓名： | Li Rongchang Gao Fei and Wang Kui (Department of Inorganic Chemistry Beijmg Medical University Beijing) |
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| 作者单位： | Department of Inorganic Chemistry，Beijmg Medical University，Beijing |
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| 基金项目： | This study was supported by National Natural Science Foundation of China. |
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| 摘 要： | Cd, Zn-thionelns were isolated from the rat liver by improved Winge method and purified further. The composition was determined. The mobilization of Cd ions from the Cd, Zn-metallothioneins was studied with spectrophotometric method. The results show that the reaction of DTP A or EDTA with Cd, Zn-thioneins occurs through three steps. The first step follows pseudo-first order reaction with association mechanism. The formation constants and the dissociation rate constants of the relevant intermediate ternary complexes and apparent rate constants, Kapp were determined. The properties and structure of Cd, Zn-thioneins and ligands with low molecular weights affect the values of Kapp.
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Kinetic Studies on Ligand Substitution Reactions of Metallothioneins with DTPA and EDTA |
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| Li Rongchang,Gao Fei and Wang Kui. Kinetic Studies on Ligand Substitution Reactions of Metallothioneins with DTPA and EDTA[J]. Chemical Research in Chinese University, 1990, 0(1) |
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| Authors: | Li Rongchang Gao Fei Wang Kui |
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| Abstract: | Cd, Zn-thionelns were isolated from the rat liver by improved Winge method and purified further. The composition was determined. The mobilization of Cd ions from the Cd, Zn-metallothioneins was studied with spectrophotometric method. The results show that the reaction of DTP A or EDTA with Cd, Zn-thioneins occurs through three steps. The first step follows pseudo-first order reaction with association mechanism. The formation constants and the dissociation rate constants of the relevant intermediate ternary complexes and apparent rate constants, Kapp were determined. The properties and structure of Cd, Zn-thioneins and ligands with low molecular weights affect the values of Kapp. |
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| Keywords: | Metallothionein Substitution reactions Kinetics |
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