| 在离子液中无水碳酸钾参与的串联甲磺酸取代苯酯脱保护和芳香亲核取代反应来合成不对称二芳醚 |
| |
| 引用本文： | 徐晖,叶飞,代会苓. 在离子液中无水碳酸钾参与的串联甲磺酸取代苯酯脱保护和芳香亲核取代反应来合成不对称二芳醚[J]. 中国化学, 2008, 26(8): 1465-1468. DOI: 10.1002/cjoc.200890266 |
| |
| 作者姓名： | 徐晖 叶飞 代会苓 |
| |
| 作者单位： | 西北农林科技大学理学院 药物合成实验室 陕西杨凌 712100 |
| |
| 摘 要： | 本文报道了一种在离子液[Bmim]BF4中，由无水碳酸钾参与的串联甲磺酸取代苯酯脱保护和芳香亲核取代反应来合成不对称二芳醚的方法。离子液可以循环使用多次，而且此实验操作具有便捷、实用与环境友好的特点。
|
| 关 键 词： | 离子液；二芳醚；甲磺酸取代苯酯；偶联；芳香亲核取代 |
| 收稿时间： | 2007-12-20 |
| 修稿时间： | 2008-03-04 |
Anhydrous K2CO3‐mediated Tandem Deprotection of (Un)substituted Phenyl Methanesulfonate/SNAr Reactions to Construct Unsymmetrical Diphenyl Ethers in an Ionic Liquid |
| |
| Hui XU,Fei YE,Hui‐Ling DAI. Anhydrous K2CO3‐mediated Tandem Deprotection of (Un)substituted Phenyl Methanesulfonate/SNAr Reactions to Construct Unsymmetrical Diphenyl Ethers in an Ionic Liquid[J]. Chinese Journal of Chemistry, 2008, 26(8): 1465-1468. DOI: 10.1002/cjoc.200890266 |
| |
| Authors: | Hui XU Fei YE Hui‐Ling DAI |
| |
| Affiliation: | 1. Tel.: 0086‐029‐87091952;2. Fax: 0086‐029‐87091952;3. Laboratory of Pharmaceutical Synthesis, College of Science, Northwest Agriculture & Forestry University, Yangling 712100, China |
| |
| Abstract: | In an ionic liquid [Bmim]BF4 (1‐butyl‐3‐methylimidazolium tetrafluoroborate), an efficient anhydrous K2CO3‐mediated tandem deprotection of (un)substituted phenyl methanesulfonates and nucleophilic aromatic substitution reactions (SNAr) with activated (un)substituted phenyl halides to synthesize unsymmetrical diphenyl ethers has been described. The solvent could be recycled without loss of any efficiency, and the procedure was quite convenient, practical and environmentally benign. |
| |
| Keywords: | ionic liquid diaryl ether (un)substituted phenyl methanesulfonate cross‐coupling, nucleophilic aromatic substitution |
|
| 点击此处可从《中国化学》浏览原始摘要信息 |
|
点击此处可从《中国化学》下载全文 |
