One‐Pot Green Synthesis of Thiazolo[3,2‐a]pyridine Derivatives via Tandem Cyclization in Aqueous Media |
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| Authors: | Muthusamy Boominathan Muthupandi Nagaraj Chellaiah Maheshwaran Shanmugam Muthusubramanian Nattamai Bhuvanesh |
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| Institution: | 1. Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, India;2. X‐ray Diffraction Laboratory, Department of Chemistry, Texas A&M University, College Station, TX, USA |
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| Abstract: | Facile, three‐component domino reactions of readily available thioglycolic acid/ethyl thioglycolate, aromatic aldehydes, and malononitrile/ethyl cyanoacetate in aqueous potassium carbonate at room temperature afforded thiazolo3,2‐a]pyridine derivatives chemoselectively in good to excellent yield. All the formed 4H‐chromenes were characterized by spectral and X‐ray methods. |
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| Keywords: | Thiazolo[3 2‐a]pyridine green synthesis |
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