Microwave‐Assisted Synthesis of Pyrrolo[2,1‐b]thiazoles Linked to a Carbohydrate Moiety |
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| Authors: | José Sebastián Barradas María Inés Errea Claudia Sepúlveda Elsa Beatriz Damonte Norma Beatriz D'Accorso |
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| Institution: | 1. CIHIDECAR‐CONICET, Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina;2. Departamento de Ingeniería Química, Instituto Tecnológico de Buenos Aires, Buenos Aires, Argentina;3. IQUIBICEN‐CONICET‐Laboratorio de Virología‐ Departamento de Química biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina |
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| Abstract: | Herein, we describe the synthesis of pyrrolo2,1‐b]thiazoles substituted on C‐2 or C‐5 with a protected carbohydrate moiety. The new fused bicyclic heterocycles were obtained via thiazole intermediates, and the N‐alkylation step was assisted by microwave irradiation. The new products were completely characterized by physical and spectroscopic techniques. The cytotoxicity and antiviral activity against Junín virus of the methylated derivates was also evaluated. |
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