Solid‐Phase Organic Synthesis of 1,4‐N‐Vinyl‐ and 1,4‐N‐Allyl‐Triazoles with the Sulfonate Linker |
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| Authors: | Aiying He Shouri Sheng Zhenzhong Huang Li Liu Mingzhong Cai |
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| Institution: | Institutes of Chemistry and Chemical Engineering, Jiangxi Normal University, Jiangxi, Nanchang, People's Republic of China |
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| Abstract: | Polymer‐supported 2‐azidoethyl sulfonate and 3‐azidopropyl sulfonate reagents have been developed and applied to the solid‐phase organic synthesis of 1‐vinyl‐ and 1‐allyl‐1,2,3‐triazoles, respectively, by CuI‐mediated azide‐alkyne cycloadditions and subsequent cleavage from the polymer support through elimination reaction promoted by DBU. The advantages of this new synthetic method include simple operation and high yield of the products, as well as good stability of the reagents. |
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